Professor Sarah Bray
Professor Sarah Bray is pleased to consider applications from prospective PhD students.
In many cancers unchecked proliferation is driven by inappropriate activity of signalling pathways, such as the Notch pathway. Activation of Notch results directly in changes in gene expression and the consequences differ according to the cell context. We are investigating the mechanisms that underly these different outcomes and the factors that influence whether Notch promotes growth or proliferation. We use Drosophila as our primary model, due to the powerful genetics and small genome size. As ~80% of human disease genes have orthologues in Drosophila our research with this tractable model is able to identify genes of relevance to human cancers that we subsequently study in human cells.
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Bernard, F, Krejci, A, Housden, B, Adryan, B and Bray, SJ (2010) Specificity of Notch pathway activation: Twist controls the transcriptional output in adult muscle progenitors. Development 137(16): 2633-42. Krejci A, Bernard F, Housden BE, Collins S, Bray SJ (2009) Direct Response to Notch Activation: Signaling Crosstalk and Incoherent Logic. Science Signaling 2: ra1 Goodfellow, H, Krejci, A, Moshkin, Y, Verrijzer, CP, Karch,F and Bray SJ (2007) Gene-Specific Targeting of the Histone Chaperone Asf1 to Mediate Silencing. Developmental Cell 13: 593-600.