Dr Su Metcalfe

University of Cambridge
Department of Clinical Neuroscience

Position: Senior Research Associate
Personal home page: http:// http://www.gurdon.cam.ac.uk/~su-metcalfe/

PubMed journal articles - click here

Dr Su Metcalfe is pleased to consider applications from prospective PhD students.

Research description

1: Application of nanotherapy to target endogenous neural stem cells in vivo for treatment of neurodegenerative diseases. 2: Application of targeted nanotherapy to control antigen-specific immune responses. 3: Exploitation of leukaemia inhibitory factor (LIF) as a therapy via the LIF-nano device. 4: Exploiting Nanog via MARCH-7, an E-3 ligase that controls the LIF receptor.

Research Programme
Onco-Innovation
smm1001
Recent publications:
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Key publications

Dong H, Fahmy TM, Metcalfe SM, Morton SL, Dong X, Inverardi L, Adams DB, Gao W, Wang H. (2012), ?Immuno-isolation of pancreatic islet allografts using pegylated nanotherapy leads to long-term normoglycemia in full MHC mismatch recipient mice.? PLoS One. 2012;7(12) 7 (12) Metcalfe SM (2011), ?LIF in the regulation of T-cell fate and as a potential therapeutic.? Genes Immun 12(3):157-68 Details Metcalfe SM, Fahmy TM (2011), ?Targeted nanotherapy for induction of therapeutic immune responses.? Trends Mol Med Details Metcalfe SM (2011), ?Multiple sclerosis: One protein, two healing properties.? Nature 477(7364):287-8 Details LH Thompson, RA Whiston, Y Rakhimov, C Taccioli, C Liu, , C Croce, and SM Metcalfe (2010) A LIF/Nanog axis is revealed in T lymphocytes that lack MARCH-7, a RINGv E3 ligase that regulates the LIF-receptor. Cell Cycle 9:20; 4213-422; October 15, 2010 J Park, W Gao, R Whiston, T B. Strom, S Metcalfe, and T M. Fahmy (2010) Modulation of CD4+ T Lymphocyte Lineage Outcomes with Targeted, Nanoparticle-Mediated Cytokine Delivery.  Mol Pharm 8(1):143-52;  WGao, LThompson, QZhou, PPutheti, TMFahmy, TBStrom, and Su M. Metcalfe (2009) Treg versus Th17 lymphocyte lineages are cross-regulated by LIF versus IL-6. Cell Cycle 8:9, 1444-1450, 2009.