Dr Stephen Smith

Cambridge University Hospitals NHS Foundation Trust
European Bioinformatics Institute
University of Cambridge

University departments
Department of Pathology
NHS or other affiliations
Depts. Dermatology and Clinical Pharmacology

Position: MRC clinical research fellow
Personal home page: https://sps41.github.io/Dr-Stephen-Smith-CV/

PubMed journal articles - click here

Research description

I am a clinician scientist based in Cambridge. My research is focused on using cutting edge computational and mathematical tools to understand the pathogenesis and aetiology of cancer, in particular squamous cell carcinoma. As a dermatologist and clinical pharmacologist I am ultimately driven by the need to translate the findings of fundamental scientific research into clinically relevant outcomes.

Research Programme
Cell and Molecular Biology
Methods and technologies
Bioinformatics
Computational modelling
DNA sequencing
Gene expression profiling
Genomics
Microarray
PCR
Tumour type interests
Cervix
Melanoma
Other
Keywords
Bioinformatics
Genomics
Skin
Dermatology

Key publications

Pellagatti A, Steeples V, Armstrong RN, Sharma E, Repapi E, Singh S, Sanchi A, Radujkovic A, Horn P, Dolatshad H, Roy S, Lockstone H, Taylor S, Giagounidis A, Vyas P, Schuh A, Hamblin A, Papaemmanuil E, Killick S, Malcovati L, Gavin A-C, Ho AD, Luft T, Hellström-Lindberg E, Cazzola M, Smith CWJ, Smith SP, and Boultwood J
Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations.
Blood 2018 Jun 21. pii: blood-2018-04-843771. doi: 10.1182/blood-2018-04-843771.

Smith SP, Scarpini CG, Groves IJ, Odle RI, Coleman N
Identification of host transcriptional networks showing concentration-dependent regulation by HPV16 E6 and E7 proteins in basal cervical squamous epithelial cells.
Scientific Reports Jul 2016; 6:29832. doi:10.1038/srep29832