Dr Sally Boss

University of Cambridge
Department of Chemistry

Position: Other
Personal home page: http://www.ch.cam.ac.uk/person/srb39

PubMed journal articles - click here

Research description

The aim of my research is to build ruthenium organometallic groups into validated, medicinal compounds such that the ligand efficiency of these existing compounds can be improved upon. In the longer term, it is hoped that the central approach described will set a precedent for inclusion of metal-containing fragments in libraries for fragment assembly. The capacity to dramatically increase ligand efficiency and to offer tunable lability and variable hypervalancy within a library could signal a new era in the field of fragment-based drug discovery and medicinal pharmaceuticals.

Research Programme
Recent publications:
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