Professor Stefan Marciniak

University of Cambridge
Cambridge University Hospitals NHS Foundation Trust
Royal Papworth Hospital NHS Foundation Trust

University departments: 
Department of Medicine
University institutes: 
Cambridge Institute for Medical Research
NHS or other affiliations: 
Professor of Respiratory Science, Honorary Consultant Respiratory Physician

Position: Professor
Personal home page: http://www.med.cam.ac.uk/marciniak/
Email:   sjm20@cam.ac.uk

PubMed journal articles - click here

Professor Stefan Marciniak is pleased to consider applications from prospective PhD students.

Research description: 

Proteins destined for secretion or for insertion into the cell membrane are first folded within the endoplasmic reticulum. The process of protein folding can become defective in malignancy. When the level of misfolded proteins within the endoplasmic reticulum increases, the cell is said to experience “endoplasmic reticulum stress”.

We wish to understand the cellular consequences of endoplasmic reticulum stress; in particular its effects on tissue growth and cell survival. In doing so, we hope to identify targets for the development of novel therapies.

Research Programme or Virtual Institute: 
Thoracic Cancer
Methods and technologies: 
Cell culture
Confocal microscopy
DNA sequencing
Fluorescence microscopy
Gene expression profiling
Immunohistochemistry
In situ hybridization
In vivo modelling
Microarray
Microscopy
Model organisms
PCR
Protein biochemistry
Protein purification
Proteomics
Recombinant protein expression
RNAi
Statistical analysis
Tumour type interests: 
Lung
Mesothelioma
Keywords: 

Endoplasmic reticulum stress

sjm20
Recent publications:
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Key publications: 

Z-⍺1-antitrypsin polymers impose molecular filtration in the endoplasmic reticulum after undergoing phase transition to a solid state. Chambers JE, Zubkov N, Kubánková M, Nixon-Abell J, Mela I, Abreu S, Schwiening M, Lavarda G, López-Duarte I, Dickens JA, Torres T., Kaminski CF, Holt LJ, Avezov E., Huntington JA, St George Hyslop P, Kuimova MK, Marciniak SJ. (2022). Science Advances 8:eabm2094. doi: 10.1126/sciadv.abm2094. PMID: 35394846.

Novel insights into surfactant protein C trafficking revealed through the study of a pathogenic mutant. Dickens JA, Rutherford E, Abreu S, Chambers JE, Ellis M, van Schadewijk A, Hiemstra P, Marciniak SJ (2022). Eur Respir J. 59: 2100267; doi: 10.1183/13993003.00267-2021. PMID: 34049951

Pharmacological targeting of endoplasmic reticulum stress in disease. Marciniak SJ, Chambers JE, Ron D (2022). Pharmacological targeting of endoplasmic reticulum stress in disease. Nat Rev Drug Discov. 21: 115-140. doi: 10.1038/s41573-021-00320-3. PMID: 34702991

Biological basis for novel mesothelioma therapies. Obacz J, Yung H, Shamseddin M, Linnane E, Liu X, Azad AA, Rassl DM, Fairen-Jimenez D, Rintoul RC, Nikolić MZ, Marciniak SJ. Br J Cancer. 2021 Oct;125(8):1039-1055. doi: 10.1038/s41416-021-01462-2. Epub 2021 Jul 5. PMID: 34226685

COVID-19 pneumothorax in the UK: a prospective observational study using the ISARIC WHO clinical characterisation protocol. Marciniak SJ, Farrell J, Rostron A, Smith I, Openshaw PJM, Baillie JK, Docherty A, Semple MG. Eur Respir J. 58:2100929 doi: 10.1183/13993003.00929-2021. PMID: 34083401

Use of preclinical models for malignant pleural mesothelioma. Shamseddin M, Obacz J, Garnett MJ, Rintoul RC, Francies HE, Marciniak SJ. Thorax. 2021 Nov;76(11):1154-1162. doi: 10.1136/thoraxjnl-2020-216602. Epub 2021 Mar 10. PMID: 33692175.

The integrated stress response in pulmonary disease.Emanuelli G, Nassehzadeh-Tabriz N, Morrell NW, Marciniak SJ. Eur Respir Rev. 2020 Oct 1;29(157):200184. doi: 10.1183/16000617.0184-2020. Print 2020 Sep 30. PMID: 33004527 Free PMC article.

Electron microscopy demonstrates subcellular localisation of gold-nanotubes in mesothelioma cells at 6 hours post-treatment