Professor Stefan Marciniak
Professor Stefan Marciniak is pleased to consider applications from prospective PhD students.
Proteins destined for secretion or for insertion into the cell membrane are first folded within the endoplasmic reticulum. The process of protein folding can become defective in malignancy. When the level of misfolded proteins within the endoplasmic reticulum increases, the cell is said to experience “endoplasmic reticulum stress”.
We wish to understand the cellular consequences of endoplasmic reticulum stress; in particular its effects on tissue growth and cell survival. In doing so, we hope to identify targets for the development of novel therapies.
Endoplasmic reticulum stress
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Virulence factors of Pseudomonas aeruginosa induce both the unfolded protein and integrated stress responses in airway epithelial cells.
van ‘t Wout E.F.A., van Schadewijk A., van Boxtel R., Dalton L.E., Clarke H.J., Tommassen J., Marciniak S.J.*, Hiemstra P.S.* (2015). PLoS Pathogens 11(6): e1004946. doi:10.1371/journal.ppat.1004946. *Joint senior authors
Actin dynamics tune the integrated stress response by regulatins eukaryotic initiation factor 2α dephosphorylation.
Chambers, J.E., Dalton, L.E., Clarke, H.J., Malzer, E., Dominicus, C.S., Patel, V., Moorhead, G.B.G., Ron, D., and Marciniak, S.J. (2015). eLIFE doi.org/10.7554/eLife.04872.
G-actin provides substrate-specificity to eukaryotic initiation factor 2a holophosphatase.
Chen, R., Rato, C., Yan, Y., Crespillo-Casado, A., Clarke, H.J., Harding, H.P., Marciniak, S.J. *, Read, R.J. *, and Ron, D*. (2015). eLIFE doi.org/10.7554/eLife.04871. *Joint senior authors
Endoplasmic reticulum stress in malignancy. (2014). Clarke H.J., Chambers J.C., Liniker E. & Marciniak S.J. (2014). Cancer Cell 25: 563-573.