Professor Stefan Marciniak

University of Cambridge
Cambridge University Hospitals NHS Foundation Trust
Royal Papworth Hospital NHS Foundation Trust

University departments
Department of Medicine
University institutes
Cambridge Institute for Medical Research
NHS or other affiliations
Professor of Respiratory Science, Honorary Consultant Respiratory Physician

Position: Professor
Personal home page: http://www.med.cam.ac.uk/marciniak/
Email:   Public email address:  sjm20@cam.ac.uk

PubMed journal articles - click here

Professor Stefan Marciniak is pleased to consider applications from prospective PhD students.

Research description

Proteins destined for secretion or for insertion into the cell membrane are first folded within the endoplasmic reticulum. The process of protein folding can become defective in malignancy. When the level of misfolded proteins within the endoplasmic reticulum increases, the cell is said to experience “endoplasmic reticulum stress”.

We wish to understand the cellular consequences of endoplasmic reticulum stress; in particular its effects on tissue growth and cell survival. In doing so, we hope to identify targets for the development of novel therapies.

Research Programme
Aerodigestive Cancer
Methods and technologies
Cell culture
Confocal microscopy
DNA sequencing
Fluorescence microscopy
Gene expression profiling
Immunohistochemistry
In situ hybridization
In vivo modelling
Microarray
Microscopy
Model organisms
PCR
Protein biochemistry
Protein purification
Proteomics
Recombinant protein expression
RNAi
Statistical analysis
Tumour type interests
Lung
Mesothelioma
Keywords

Endoplasmic reticulum stress

sjm20
Recent publications:
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Key publications

Virulence factors of Pseudomonas aeruginosa induce both the unfolded protein and integrated stress responses in airway epithelial cells.
van ‘t Wout E.F.A., van Schadewijk A., van Boxtel R., Dalton L.E., Clarke H.J., Tommassen J., Marciniak S.J.*, Hiemstra P.S.* (2015). ­­PLoS Pathogens 11(6): e1004946. doi:10.1371/journal.ppat.1004946. *Joint senior authors

Actin dynamics tune the integrated stress response by regulatins eukaryotic initiation factor 2α dephosphorylation.
Chambers, J.E., Dalton, L.E., Clarke, H.J., Malzer, E., Dominicus, C.S., Patel, V., Moorhead, G.B.G., Ron, D., and Marciniak, S.J. (2015). eLIFE doi.org/10.7554/eLife.04872.

G-actin provides substrate-specificity to eukaryotic initiation factor 2a holophosphatase.
Chen, R., Rato, C., Yan, Y., Crespillo-Casado, A., Clarke, H.J., Harding, H.P., Marciniak, S.J. *, Read, R.J. *, and Ron, D*. (2015). eLIFE doi.org/10.7554/eLife.04871. *Joint senior authors

Endoplasmic reticulum stress in malignancy. (2014). Clarke H.J., Chambers J.C., Liniker E. & Marciniak S.J. (2014). Cancer Cell 25: 563-573.

Malignant mesothelioma stained for GADD34 (PPP1R15A) [from Dalton et al. (2013) The endoplasmic reticulum stress marker CHOP predicts survival in malignant mesothelioma. Br J Cancer 108: 1340-7]