Mr Sujath Abbas

University of Cambridge

University departments
MRC Cancer Unit
University institutes
Hutchison MRC Research Centre

Position: PhD student
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PubMed journal articles - click here

Research description

With an interest in cancer genomics and early detection, I joined the Fitzgerald group in July 2016 as a British council sponsored-visiting researcher, before starting my PhD in October 2017. My research is focused on to investigate the different mutational processes operating in the development of oesophageal adenocarcinoma (EAC) by studying associated mutational signatures in these patient samples, so as to gain insights about the aetiology and clinical management of EAC.

I obtained my master’s and bachelor’s in Biochemistry from Kuvempu and Tumkur Universities in Karnataka state, India. I then joined Cancer Genetics lab at Tata Memorial Centre’s Advanced Centre for Treatment Research and Education in Cancer (ACTREC) in Mumbai, working on inherited breast and ovarian cancer syndrome, before coming to Cambridge.

My PhD is supported by Cambridge Commonwealth European and International Trust, Trinity College’s Henry Barlow and Sidney Sussex College’s Howard scholarships.

Research Programme
Early Detection
Methods and technologies
Cell culture
DNA sequencing
Gene expression profiling
Tumour type interests

Key publications

The mutREAD method detects mutational signatures from low quantities of cancer DNA. Nat Commun 11, 3166 (2020).
Perner, J., Abbas, S., Nowicki-Osuch, K. et al. .

mutREAD: An affordable method to capture the archaeology of DNA damaging events in cancer genomes.
Behind the paper; Nature Research Cancer Community Blog July27,2020
Author:Sujath Abbas Contributing authors: Juliane Perner, Karol Nowicki-Osuch, Rebecca Fitzgerald

The landscape of selection in 551 esophageal adenocarcinomas defines genomic biomarkers for the clinic. Frankell AM, Jammula S, Li X, Contino G, Killcoyne S, Abbas S, Perner J, Bower L, Devonshire G, Ococks E, Grehan N, Mok J, O'Donovan M, MacRae S, Eldridge MD, Tavaré S; Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium, Fitzgerald RC. Nat Genet 51, 506–516 (2019).

Identification of Subtypes of Barrett's Esophagus and Esophageal Adenocarcinoma Based on DNA Methylation Profiles and Integration of Transcriptome and Genome Data
SriGanesh Jammula, Annalise C Katz-Summercorn, Xiaodun Li, Constanza Linossi, Elizabeth Smyth, Sarah Killcoyne, Daniele Biasci, Vinod V Subash, Sujath Abbas, Adrienn Blasko, Ginny Devonshire, Amber Grantham, Filip Wronowski, Maria O'Donovan, Nicola Grehan, Mathew D Eldridge, Simon Tavaré, Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) consortium, Rebecca C Fitzgerald.Gastroenterology, 2020 Feb 4
PMID: 32032585 DOI: 10.1053/j.gastro.2020.01.044

Genomic copy number predicts oesophageal cancer years before transformation
Sarah Killcoyne, Eleanor Gregson, David C Wedge,Dan J Woodcock, Matthew Eldridge, Rachel de la Rue, Ahmad Miremadi, Sujath Abbas, Adrienn Blasko, Wladyslaw Januszewicz, Aikaterini Varanou Jenkins,Moritz Gerstung, Rebecca C Fitzgerald
BioRxiv doi: