Dr Svetlana Khoronenkova

University of Cambridge

University departments
Department of Biochemistry

Position: Sir Henry Dale Fellow
Personal home page: http://www.bioc.cam.ac.uk/people/uto/khoronenkova

PubMed journal articles - click here

Research description

We are interested in understanding of the links between deficiencies in the DNA damage response and the molecular nature of disease.

Human cells repair thousands of DNA lesions daily. The majority of lesions arise from the intrinsic chemical instability of DNA and include single-strand breaks and base modifications. Unrepaired lesions can obstruct DNA replication, leading to mutations and toxic DNA double-strand breaks. In non-proliferating cells (for example, post-mitotic neurons) damaged DNA bases and single-strand breaks can block transcription, leading to cell death and disease. In particular, defects in DNA repair are often linked to cancer and progressive neurological disorders, although their precise roles in the malignant and neurological phenotypes remain elusive.

This work is supported by the Royal Society and the Wellcome Trust.

Research Programme or Virtual Institute
Fundamental Biology of Cancer
Methods and technologies
Cell culture
Confocal microscopy
Fluorescence microscopy
Protein biochemistry
Protein purification
Recombinant protein expression
Tumour type interests
DNA repair
DNA damage signalling
DNA single-strand breaks
Recent publications:
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Key publications

1. Khoronenkova SV & Dianov GL (2015) ATM prevents DSB formation by coordinating SSB repair and cell cycle progression. Proc. Natl. Acad. Sci. 112,
2. Khoronenkova SV & Dianov GL (2013) USP7S-dependent inactivation of Mule regulates DNA damage signaling and repair. Nucl. Acids Res. 41, 1750-1756.
3. Khoronenkova SV, Dianova II, Edelmann MJ, Kessler BM, Parsons JL, & Dianov GL (2012) ATM-dependent down-regulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage. Mol. Cell 45, 801-813.