Dr Ultan McDermott
Position: Faculty & Group Leader
Personal home page: http://www.sanger.ac.uk/research/faculty/umcdermott/
PubMed journal articles - click here
Dr Ultan McDermott is pleased to consider applications from prospective PhD students.
Advances in genome sequencing technologies are enabling researchers to make rapid progress in defining the entire repertoire of causal genetic changes in cancer. The response of patients with cancer to therapy is often highly variable and there are an increasing number of examples where mutations in cancer genomes have been shown to have a profound effect on the clinical effectiveness of drugs. The use of large-scale cell line-based drug screens to identify genomic 'biomarkers' of drug response for the stratification of patients has the potential to transform how patients with cancer are treated. Moreover, for the first time we have the ability to identify clinically relevant patterns of mutations and copy number alterations using thousands of primary tumour exomes from the International Cancer Genome Consortium and to prioritise these for analysis using such cell line-based screens.
Garnett MJ, Edelman EJ, Heidorn SJ, Greenman CD, e al. (2012) Systematic identification of genomic markers of drug sensitivity in cancer cells. Nature 28;483(7391):570-5. Huang S, Hölzel M, Knijnenburg T, Schlicker A, Roepman P, McDermott U, Garnett M, et al. MED12 Controls the Response to Multiple Cancer Drugs through Regulation of TGF-? Receptor Signaling. Cell. 2012 Nov 21;151(5):937-50. McDermott U, Sharma SV, Dowell L, Greninger P, et al. Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling. (2007) Proc Natl Acad Sci U S A 104(50):19936-41.